Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors

SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3344-3348
Hauptverfasser:	Bueno, Ana B, Gilmore, Jeremy, Boot, John, Broadmore, Richard, Cooper, Jane, Findlay, Jeremy, Hayhurst, Lorna, Marcos, Alicia, Montero, Carlos, Mitchell, Stephen, Timms, Graham, Tomlinson, Rosemarie, Wallace, Louise, Walton, Leslie
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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