Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors

Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors

SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3344-3348
Hauptverfasser: Bueno, Ana B, Gilmore, Jeremy, Boot, John, Broadmore, Richard, Cooper, Jane, Findlay, Jeremy, Hayhurst, Lorna, Marcos, Alicia, Montero, Carlos, Mitchell, Stephen, Timms, Graham, Tomlinson, Rosemarie, Wallace, Louise, Walton, Leslie
Format: Artikel
Sprache:eng
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Zusammenfassung:SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.03.101