Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors
SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3344-3348 |
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Sprache: | eng |
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| container_end_page | 3348 |
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| container_issue | 12 |
| container_start_page | 3344 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 17 |
| creator | Bueno, Ana B Gilmore, Jeremy Boot, John Broadmore, Richard Cooper, Jane Findlay, Jeremy Hayhurst, Lorna Marcos, Alicia Montero, Carlos Mitchell, Stephen Timms, Graham Tomlinson, Rosemarie Wallace, Louise Walton, Leslie |
| description | SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)). |
| doi_str_mv | 10.1016/j.bmcl.2007.03.101 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3344-3348 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19516543 |
| source | Access via ScienceDirect (Elsevier) |
| title | Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors |
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