First trimester screening for pre‐eclampsia in Chinese pregnancies: case–control study

Objective To assess the potential of screening for pre‐eclampsia (PE) in a Chinese population. Design Case–control study. Setting Teaching hospital in Hong Kong. Population A total of 3330 women having a viable singleton pregnancy attending first‐trimester Down‐syndrome screening. Methods Mean arterial pressure (MAP), bilateral uterine artery pulsatility index (UtA‐PI), and placental growth factor (PlGF) were measured. Screening markers were transformed to multiples of the gestational median (MoM) and adjusted for maternal and pregnancy characteristics. MoM distributions in PE and non‐PE pregnancies were compared with published expected values. PE screening performance was assessed using area under receiver operating curves (AUROC). Main outcome measures PE detection rate. Results A total of 30 (0.9%) women developed either early (