Identification of a novel CSF3R-SPTAN1 fusion gene in an atypical chronic myeloid leukemia patient with t(1;9)(p34;q34) by RNA -seq

Highlights • CSF3R rearrangement is firstly found in hematological neoplasms. • The patient with CSF3R-SPTAN1 fusion showed a poor response to dasatinib therapy.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer genetics 2017-10, Vol.216-217, p.16-19
Hauptverfasser:	Sheng, Guangying, Zhang, Jian, Zeng, Zhao, Pan, Jinlan, Wang, Qinrong, Wen, Lijun, Xu, Yang, Wu, Depei, Chen, Suning
Format:	Artikel
Sprache:	eng
Schlagworte:	Atypical CML Base Sequence Chromosomes, Human - genetics CSF3R dasatinib Female fusion Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics Medical Education Microfilament Proteins - genetics Oncogene Proteins, Fusion - genetics Receptors, Colony-Stimulating Factor - genetics Sequence Analysis, RNA - methods SPTAN1 Translocation, Genetic Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • CSF3R rearrangement is firstly found in hematological neoplasms. • The patient with CSF3R-SPTAN1 fusion showed a poor response to dasatinib therapy.
ISSN:	2210-7762 2210-7770
DOI:	10.1016/j.cancergen.2017.05.002