3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank/Rankl/OPG
3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in term...
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Veröffentlicht in: | Materials Science & Engineering C 2018-01, Vol.82, p.244-252 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG. Those findings indicated that GO-np may be potentially used to control the release of carrier materials and influence the signal pathway of Rank/Rankl/OPG.
•3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate.•Graphene oxide nano particels (GO-np) have been used as a delivery vehicle.•Hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG. |
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ISSN: | 0928-4931 1873-0191 |
DOI: | 10.1016/j.msec.2017.08.069 |