Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial

BACKGROUND: Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown. OBJECTIVE: We assessed visual responses of preterm infants fed human milk (HM) and formula with a DHA con...

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Veröffentlicht in:	The American journal of clinical nutrition 2008-10, Vol.88 (4), p.1049-1056
Hauptverfasser:	Smithers, Lisa G, Gibson, Robert A, McPhee, Andrew, Makrides, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Babies Biological and medical sciences Birth Weight - physiology Body Height - physiology Body Weight - physiology breast feeding Breastfeeding & lactation docosahexaenoic acid Docosahexaenoic Acids - administration & dosage dose response Dose-Response Relationship, Drug Double-Blind Method evoked potentials Evoked Potentials, Visual fatty acid composition Fatty acids Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans infant development Infant Formula - chemistry infant formulas Infant Nutritional Physiological Phenomena - physiology Infant, Newborn Infant, Premature infants Male Milk, Human - chemistry mothers Neonatal care neonates Nutrition nutritional intervention Nutritional Requirements premature birth preterm infants randomized clinical trials Vertebrates: anatomy and physiology, studies on body, several organs or systems vision visual acuity Visual Acuity - drug effects Visual Acuity - physiology
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Zusammenfassung:	BACKGROUND: Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown. OBJECTIVE: We assessed visual responses of preterm infants fed human milk (HM) and formula with a DHA concentration estimated to match the intrauterine accretion rate (high-DHA group) compared with infants fed HM and formula containing DHA at current concentrations. DESIGN: A double-blind randomized controlled trial studied preterm infants born at
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/88.4.1049