Substance P receptor mediated maintenance of chronic inflammation in EAE

Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high CD4+ T cells and MOG-specific, IFN-γ produc...

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Veröffentlicht in:Journal of neuroimmunology 2006-11, Vol.180 (1), p.117-125
Hauptverfasser: Reinke, Emily K., Johnson, Matthew J., Ling, Changying, Karman, Jozsef, Lee, JangEun, Weinstock, Joel V., Sandor, Matyas, Fabry, Zsuzsa
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Sprache:eng
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Zusammenfassung:Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high CD4+ T cells and MOG-specific, IFN-γ producing CD4+ T cells. SR140333, an NK-1 antagonist, administered alone during the chronic phase of EAE was not sufficient to ameliorate symptoms. These results indicate that SP, through NK-1, contributes to maintenance of CNS inflammation, and combining NK-1 antagonists with conventional anti-inflammatory treatments may enhance the success of treatments for diseases like multiple sclerosis.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2006.07.010