Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection Reduces Recurrent Urinary Tract Infection Frequency

Broad-spectrum antibiotics for recurrent multidrug-resistant urinary tract infections (UTIs) disrupt the gut microbiome and promote antibiotic resistance. Fecal microbiota transplantation led to resolution of recurrent Clostridium difficile, significantly decreased recurrent UTI frequency, and impro...

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Veröffentlicht in:	Clinical infectious diseases 2017-11, Vol.65 (10), p.1745-1747
Hauptverfasser:	Tariq, Raseen, Pardi, Darrell S., Tosh, Pritish K., Walker, Randall C., Razonable, Raymund R., Khanna, Sahil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Bacteria BRIEF REPORTS Clostridium difficile Clostridium difficile - drug effects Clostridium Infections - complications Clostridium Infections - drug therapy Clostridium Infections - epidemiology Clostridium Infections - therapy Drug resistance Fecal Microbiota Transplantation Fecal microflora Feces Female Humans Intestinal microflora Male Microbial Sensitivity Tests Microbiomes Microbiota Multidrug resistance Recurrence Recurrent infection Retrospective Studies Transplantation Urinary tract Urinary tract infections Urinary Tract Infections - complications Urinary Tract Infections - epidemiology
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Zusammenfassung:	Broad-spectrum antibiotics for recurrent multidrug-resistant urinary tract infections (UTIs) disrupt the gut microbiome and promote antibiotic resistance. Fecal microbiota transplantation led to resolution of recurrent Clostridium difficile, significantly decreased recurrent UTI frequency, and improved antibiotic susceptibility profile of UTI-causing organisms.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix618