Recurrent Atypical Hemolytic Uremic Syndrome in Children With Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Recurrent Atypical Hemolytic Uremic Syndrome in Children With Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemoth...

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Veröffentlicht in:Journal of pediatric hematology/oncology 2018-10, Vol.40 (7), p.560-562
Hauptverfasser: Cheng, Geoffrey, Ozgonenel, Bulent, Bhambhani, Kanta, Kapur, Gaurav, Smith, Richard J, Savaşan, Süreyya
Format: Artikel
Sprache:eng
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Zusammenfassung:Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.
ISSN:1077-4114
1536-3678
DOI:10.1097/MPH.0000000000000987