Acute kidney injury in necrotizing enterocolitis predicts mortality

Acute kidney injury in necrotizing enterocolitis predicts mortality

Background Morbidity and mortality with necrotizing enterocolitis (NEC) remains a significant challenge. Acute kidney injury (AKI) has been shown to worsen survival in critically ill neonates. To our knowledge, this study is the first to evaluate the prevalence of AKI and its impact on outcomes in n...

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Veröffentlicht in:Pediatric nephrology (Berlin, West) West), 2018-03, Vol.33 (3), p.503-510
Hauptverfasser: Criss, Cory N., Selewski, David T., Sunkara, Bipin, Gish, Joshua S., Hsieh, Lily, Mcleod, Jennifer S., Robertson, Jason O., Matusko, Niki, Gadepalli, Samir K.
Format: Artikel
Sprache:eng
Schlagworte:
Acute kidney failure
Acute Kidney Injury - complications
Acute Kidney Injury - epidemiology
Acute Kidney Injury - mortality
Analysis
Creatinine
Databases, Factual
Development and progression
Diagnosis
Dialysis
Enterocolitis
Enterocolitis, Necrotizing - complications
Enterocolitis, Necrotizing - mortality
Female
Gastrointestinal diseases
Gentamicin
Hospital Mortality
Humans
Infant
Infant Mortality
Infant, Newborn
Kidneys
Length of Stay - statistics & numerical data
Male
Medicine
Medicine & Public Health
Michigan - epidemiology
Morbidity
Mortality
Necrosis
Necrotizing enterocolitis
Neonates
Nephrology
Newborn babies
Original Article
Patient outcomes
Pediatrics
Prevalence
Retrospective Studies
Risk Factors
Surgery
Urology
Vancomycin
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Zusammenfassung:Background Morbidity and mortality with necrotizing enterocolitis (NEC) remains a significant challenge. Acute kidney injury (AKI) has been shown to worsen survival in critically ill neonates. To our knowledge, this study is the first to evaluate the prevalence of AKI and its impact on outcomes in neonatal NEC. Methods We carried out a single-center retrospective chart review of all neonates treated for NEC between 2003 and 2015 ( N  = 181). AKI is defined as a rise in serum creatinine (SCr) from a previous trough according to neonatal modified KDIGO criteria (stage 1 = SCr rise 0.3 mg/dL or SCr 150 
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-017-3809-y