Clinical and epidemiological differences between men and women with systemic sclerosis: a study in a Spanish systemic sclerosis cohort and literature review

The low overall prevalence of systemic sclerosis (SSc) and the low proportion of male patients have resulted in a scarcity of studies assessing sex differences in Ssc patients, and contradictory results have often been show among those studies that have been performed. A prospective study was conduc...

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Veröffentlicht in:Clinical and experimental rheumatology 2017-09, Vol.35 Suppl 106 (4), p.89-97
Hauptverfasser: Freire, Mayka, Rivera, Alberto, Sopeña, Bernardo, Tolosa Vilella, Carles, Guillén-Del Castillo, Alfredo, Colunga Argüelles, Dolores, Callejas Rubio, Jose Luis, Rubio Rivas, Manuel, Trapiella Martínez, Luis, Todolí Parra, Jose Antonio, Rodríguez Carballeira, Mónica, Iniesta Arandia, Nerea, García Hernández, Francisco José, Egurbide Arberas, María Victoria, Sáez Comet, Luis, Vargas Hitos, Jose Antonio, Ríos Blanco, Juan José, Marín Ballvé, Adela, Pla Salas, Xavier, Madroñero Vuelta, Ana Belén, Ruiz Muñoz, Manuel, Fonollosa Pla, Vicent, Simeón Aznar, Carmen Pilar
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Sprache:eng
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Zusammenfassung:The low overall prevalence of systemic sclerosis (SSc) and the low proportion of male patients have resulted in a scarcity of studies assessing sex differences in Ssc patients, and contradictory results have often been show among those studies that have been performed. A prospective study was conducted with the Spanish RESCLE register to analyse the influence of gender on survival of SSc patients. In total, 1506 SSc patients (1341 women, 165 men) were recruited from 21 centres. Older age at onset (OR 1.02), shorter time from onset to diagnosis (OR 0.96), smoking (OR 2.57), interstitial lung disease (ILD) (OR 1.58), less predisposition to sicca syndrome and to antinuclear antibody positivity (OR 0.29 and 0.43, respectively), and higher compliance with the ACR 1980 criteria (OR 1.79) were independently associated with the male sex. During follow-up, 30.4% of men versus 14.6% of women died (p
ISSN:0392-856X