Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis
This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms after a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patien...
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| Veröffentlicht in: | Journal of neurotrauma 2018-02, Vol.35 (4), p.609-622 |
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| creator | Mercier, Eric Tardif, Pier-Alexandre Cameron, Peter A Batomen Kuimi, Brice Lionel Émond, Marcel Moore, Lynne Mitra, Biswadev Frenette, Jérôme De Guise, Elaine Ouellet, Marie-Christine Bordeleau, Martine Le Sage, Natalie |
| description | This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms after a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomized as persistent (≥3 months) or early (≥7 days |
| doi_str_mv | 10.1089/neu.2017.5013 |
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0% [n = five studies]) in patients with an elevated S-100β protein serum level were not significantly different from those of patients with normal values while the odds of having early PCS (OR 1.67, 95% CI: 0.98-2.85, p = 0.06, I
38% [n = five studies]) were close to statistical significance. Similarly, having an elevated S-100β protein serum level was not associated with the odds of returning to work at six months (OR 2.31, 95% CI: 0.50-10.64, p = 0.28, I
22% [n = two studies]). Overall risk of bias was considered moderate. Results suggest that the prognostic biomarker S-100β protein has a low clinical value to identify patients at risk of persistent post-concussion symptoms. Variability in injury to S-100ß protein sample time, mTBI populations, and outcomes assessed could potentially explain the lack of association and needs further evaluation.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2017.5013</identifier><identifier>PMID: 28969486</identifier><language>eng</language><publisher>United States</publisher><subject>Brain Concussion - blood ; Brain Concussion - complications ; Humans ; Post-Concussion Syndrome - blood ; Post-Concussion Syndrome - diagnosis ; Prognosis ; S100 Calcium Binding Protein beta Subunit - blood</subject><ispartof>Journal of neurotrauma, 2018-02, Vol.35 (4), p.609-622</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-e438fa291c13d49531006b527c3a9892a02d06f61eaa9f1081f0a5735ab0a7a63</citedby><cites>FETCH-LOGICAL-c293t-e438fa291c13d49531006b527c3a9892a02d06f61eaa9f1081f0a5735ab0a7a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28969486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mercier, Eric</creatorcontrib><creatorcontrib>Tardif, Pier-Alexandre</creatorcontrib><creatorcontrib>Cameron, Peter A</creatorcontrib><creatorcontrib>Batomen Kuimi, Brice Lionel</creatorcontrib><creatorcontrib>Émond, Marcel</creatorcontrib><creatorcontrib>Moore, Lynne</creatorcontrib><creatorcontrib>Mitra, Biswadev</creatorcontrib><creatorcontrib>Frenette, Jérôme</creatorcontrib><creatorcontrib>De Guise, Elaine</creatorcontrib><creatorcontrib>Ouellet, Marie-Christine</creatorcontrib><creatorcontrib>Bordeleau, Martine</creatorcontrib><creatorcontrib>Le Sage, Natalie</creatorcontrib><title>Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms after a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomized as persistent (≥3 months) or early (≥7 days <3 months). Our search strategy yielded 23,298 citations of which 29 studies including between seven and 223 patients (n = 2505) were included. Post-concussion syndrome (PCS) (16 studies) and neuropsychological symptoms (9 studies) were the most frequently assessed outcomes. The odds of having persistent PCS (odds ratio [OR] 0.62, 95% confidence interval [CI]: 0.34-1.12, p = 0.11, I
0% [n = five studies]) in patients with an elevated S-100β protein serum level were not significantly different from those of patients with normal values while the odds of having early PCS (OR 1.67, 95% CI: 0.98-2.85, p = 0.06, I
38% [n = five studies]) were close to statistical significance. Similarly, having an elevated S-100β protein serum level was not associated with the odds of returning to work at six months (OR 2.31, 95% CI: 0.50-10.64, p = 0.28, I
22% [n = two studies]). Overall risk of bias was considered moderate. Results suggest that the prognostic biomarker S-100β protein has a low clinical value to identify patients at risk of persistent post-concussion symptoms. Variability in injury to S-100ß protein sample time, mTBI populations, and outcomes assessed could potentially explain the lack of association and needs further evaluation.</description><subject>Brain Concussion - blood</subject><subject>Brain Concussion - complications</subject><subject>Humans</subject><subject>Post-Concussion Syndrome - blood</subject><subject>Post-Concussion Syndrome - diagnosis</subject><subject>Prognosis</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1OHDEQhS1EBAPJki3yko0n_uk_syOjBJBAICDZtmq6y8io257YbqI5Se7BQXKmuDUkq7LqfX623iPkRPCl4I3-7HBaSi7qZcmF2iMLUZY107yQ-2SR9ZrVohSH5CjGF56JStYH5FA2utJFUy3I7_vgn52PyXb0BwwTUm_oIxOc_3mjWUtoHTU-5DP2tkvWu5m4zzfYyrtuinFePW7HTfJjpGASBgr01g49fQowjTBbfwmQfa7dyxS255mOCXfCA75a_EXB9fQWE7ALB8M22viRfDAwRPz0Po_J929fn1ZX7Obu8np1ccM6qVViWKjGgNSiE6ovdKnyx6t1KetOgW60BC57XplKIIA2OTBhOJS1KmHNoYZKHZOzne8m-J8TxtSONnY4DODQT7EVuqjyG7IpMsp2aBd8jAFNuwl2hLBtBW_nLtrcRTt30c5dZP703Xpaj9j_p_-Fr_4CPwCGig</recordid><startdate>20180215</startdate><enddate>20180215</enddate><creator>Mercier, Eric</creator><creator>Tardif, Pier-Alexandre</creator><creator>Cameron, Peter A</creator><creator>Batomen Kuimi, Brice Lionel</creator><creator>Émond, Marcel</creator><creator>Moore, Lynne</creator><creator>Mitra, Biswadev</creator><creator>Frenette, Jérôme</creator><creator>De Guise, Elaine</creator><creator>Ouellet, Marie-Christine</creator><creator>Bordeleau, Martine</creator><creator>Le Sage, Natalie</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180215</creationdate><title>Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis</title><author>Mercier, Eric ; 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A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomized as persistent (≥3 months) or early (≥7 days <3 months). Our search strategy yielded 23,298 citations of which 29 studies including between seven and 223 patients (n = 2505) were included. Post-concussion syndrome (PCS) (16 studies) and neuropsychological symptoms (9 studies) were the most frequently assessed outcomes. The odds of having persistent PCS (odds ratio [OR] 0.62, 95% confidence interval [CI]: 0.34-1.12, p = 0.11, I
0% [n = five studies]) in patients with an elevated S-100β protein serum level were not significantly different from those of patients with normal values while the odds of having early PCS (OR 1.67, 95% CI: 0.98-2.85, p = 0.06, I
38% [n = five studies]) were close to statistical significance. Similarly, having an elevated S-100β protein serum level was not associated with the odds of returning to work at six months (OR 2.31, 95% CI: 0.50-10.64, p = 0.28, I
22% [n = two studies]). Overall risk of bias was considered moderate. Results suggest that the prognostic biomarker S-100β protein has a low clinical value to identify patients at risk of persistent post-concussion symptoms. Variability in injury to S-100ß protein sample time, mTBI populations, and outcomes assessed could potentially explain the lack of association and needs further evaluation.</abstract><cop>United States</cop><pmid>28969486</pmid><doi>10.1089/neu.2017.5013</doi><tpages>14</tpages></addata></record> |
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| subjects | Brain Concussion - blood Brain Concussion - complications Humans Post-Concussion Syndrome - blood Post-Concussion Syndrome - diagnosis Prognosis S100 Calcium Binding Protein beta Subunit - blood |
| title | Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis |
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