Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis

This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms after a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patien...

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Veröffentlicht in:Journal of neurotrauma 2018-02, Vol.35 (4), p.609-622
Hauptverfasser: Mercier, Eric, Tardif, Pier-Alexandre, Cameron, Peter A, Batomen Kuimi, Brice Lionel, Émond, Marcel, Moore, Lynne, Mitra, Biswadev, Frenette, Jérôme, De Guise, Elaine, Ouellet, Marie-Christine, Bordeleau, Martine, Le Sage, Natalie
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Sprache:eng
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Zusammenfassung:This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms after a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomized as persistent (≥3 months) or early (≥7 days
ISSN:0897-7151
1557-9042
DOI:10.1089/neu.2017.5013