Integrating photoluminescence, magnetism and thermal conversion for potential photothermal therapy and dual-modal bioimaging

The MWCNTs-NaGdF4:Yb3+, Er3+, Eu3+ multifunctional nanocomposites with magnetic, luminescent and thermal conversion properties were fabricated by a facile hydrothermal method, the up-conversion luminescence imaging, X-ray computed tomography imaging and photothermal therapy of nanocomposites were investigated. The obtained nanocomposites would have promising applications in diagnosis and therapy of tumors. [Display omitted] Multifunctional nanocomposites (NCs) incorporating magnetic, luminescent and photothermal conversion properties are endowed with potential application in many fields such as imaging, tumor detection, drug delivery and therapy. Here, multifunctional MWCNTs-NaGdF4:Yb3+, Er3+, Eu3+ NCs, which offer the potential for integrated bioimaging and photothermal therapy (PTT) were fabricated by a facile hydrothermal method. The resulting sample exhibits uniform morphology, bright dual-modal luminescence and intrinsic paramagnetic properties. Under near-infrared laser excitation, NCs have excellent photothermal conversion properties. In addition, the MTT assay in HeLa cells shows that the NCs have good biocompatibility. Moreover, the up-conversion luminescence (UCL) imaging, X-ray computed tomography (CT) imaging and PTT in vitro of NCs were investigated. The results indicate that NCs can be used for dual-modal imaging-guided diagnose and PTT of cancer cells.