Synthesis and Pharmacological Activity of N-[β-(para-substituted benzoyl)ethyl]isoleucine and -Methionine

Synthesis and Pharmacological Activity of N-[β-(para-substituted benzoyl)ethyl]isoleucine and -Methionine

A series of N-[ beta -(p-substituted benzoyl)ethyl]-isoleucine and -methionine derivatives have been synthesized via the alkylation of amino acids with p-substituted beta -diethylaminopropiophenone hydrochlorides. Some of the synthesized compounds possess significant antiinflammatory activity.

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Veröffentlicht in:Pharmaceutical chemistry journal 2005-07, Vol.39 (7), p.364-366
Hauptverfasser: Agababyan, A. G., Isakhanyan, A. Y., Papoyan, O. A., Tumadzhyan, A. E., Balasanyan, A. S., Gevorgyan, G. A.
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Sprache:eng
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Zusammenfassung:A series of N-[ beta -(p-substituted benzoyl)ethyl]-isoleucine and -methionine derivatives have been synthesized via the alkylation of amino acids with p-substituted beta -diethylaminopropiophenone hydrochlorides. Some of the synthesized compounds possess significant antiinflammatory activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-005-0156-2