Pharmacokinetic evaluation and studies on the clinical efficacy of guar gum- -based oral drug delivery systems of albendazole and albendazole-[beta]- cyclodextrin for colon-targeting in human volunteers

The present investigation assessed the in vivo properties of the guar gum- based colon-targeted matrix tablets of albendazole-[beta]-cyclodextrin (KA), albendazole matrix tablet (GA), and an immediate-release albendazole tablet (CA) in humans. A single oral dose was administered in healthy human volunteers and a completely randomized, two-way, three-period crossover design was adopted. The data were statistically analyzed and a value of P