Synthesis, metal complexation and biological evaluation of a novel semi- rigid bifunctional chelating agent for super(99m)Tc labelling

A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous super(99m)TcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the super(99m)Tc- complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with super(99m)Tc.