The impact of extended release exenatide as adjuvant therapy on hemoglobin A1C, weight, and total daily dose of insulin in patients with type 2 diabetes mellitus using U-500 insulin

•Retrospective chart review of off label, adjuvant exenatide ER with regular U-500 insulin.•No statistical improvement in HbA1C at 3, 6, or 12months.•Modest weight loss throughout the study period.•Statistically significant decrease in total daily dose of regular U-500 insulin. To evaluate the effic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes research and clinical practice 2017-12, Vol.134, p.38-43
Hauptverfasser: Farwig, Phillip A., Zielinski, Angela J., Accursi, Mallory L., Burant, Christopher J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Retrospective chart review of off label, adjuvant exenatide ER with regular U-500 insulin.•No statistical improvement in HbA1C at 3, 6, or 12months.•Modest weight loss throughout the study period.•Statistically significant decrease in total daily dose of regular U-500 insulin. To evaluate the efficacy and safety of adjuvant exenatide extended release (ER) therapy in patients treated with regular U-500 insulin. In this retrospective chart review at an ambulatory care center in the Midwest, 18 patients with type 2 diabetes being treated with regular U-500 insulin and adjuvant exenatide ER were identified. These patients were evaluated for outcomes following the addition of exenatide ER. The primary outcome was change in HbA1C from baseline to 3, 6, and 12months. Secondary outcomes included change in weight, total daily dose (TDD) of insulin, and hypoglycemia. Repeated measures ANOVA was performed to assess the differences in mean scores over four time periods. A total of 18 of 50 patients met inclusion criteria with sufficient data to be included in analysis. HbA1C showed non-significant findings from baseline to 12months (8.08% vs. 8.23%; p=0.75). A non-significant, modest weight loss occurred (146.4kgvs. 144.2kg; −2.2kg; p=0.31). A significant decrease in TDD of insulin was observed (378 units vs. 326 units; p
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.09.008