Spread of a single multidrug resistant malaria parasite lineage (PfPailin) to Vietnam

Initially multiple independent Kelch mutations were observed,1 but in a recent sinister development, a single dominant artemisinin-resistant P falciparum C580Y mutant lineage has arisen in western Cambodia, outcompeted the other resistant malaria parasites, and subsequently acquired resistance to pi...

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Veröffentlicht in:The Lancet infectious diseases 2017-10, Vol.17 (10), p.1022-1023
Hauptverfasser: Imwong, Mallika, Hien, Tran T, Thuy-Nhien, Nguyen T, Dondorp, Arjen M, White, Nicholas J
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Sprache:eng
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Zusammenfassung:Initially multiple independent Kelch mutations were observed,1 but in a recent sinister development, a single dominant artemisinin-resistant P falciparum C580Y mutant lineage has arisen in western Cambodia, outcompeted the other resistant malaria parasites, and subsequently acquired resistance to piperaquine.2 Cambodia had adopted dihydroartemisinin-piperaquine as first-line antimalarial treatment, but has now been forced to switch its first line artemisinin combination treatment back to artesunate-mefloquine as a consequence3. 1 EA Ashley, M Dhorda, RM Fairhurst, Plasmodium falciparum, malaria, N Engl J Med, Vol. 371, 2014, 411-423 2 M Imwong, K Suwannasin, C Kunasol, Plasmodium falciparum, in the Greater Mekong Subregion: a molecular epidemiology observational study, Lancet Infect Dis, Vol. 17, 2017, 491-497 3 World Health Organization, Status report on artemisinin and ACT resistance (April 2017), (accessed July 11, 2017).
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(17)30524-8