Evolution of Radical-Based Convergent Strategies for Total Syntheses of Densely Oxygenated Natural Products
Densely oxygenated natural products often exhibit potent bioactivities and are expected to function as selective cellular probes and novel drug leads. Here we describe our efforts to perfect radical-based convergent strategies for generic total syntheses of these exceedingly challenging structures.
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| Veröffentlicht in: | Accounts of chemical research 2017-03, Vol.50 (3), p.460-464 |
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| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Densely oxygenated natural products often exhibit potent bioactivities and are expected to function as selective cellular probes and novel drug leads. Here we describe our efforts to perfect radical-based convergent strategies for generic total syntheses of these exceedingly challenging structures. |
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| ISSN: | 0001-4842 1520-4898 |
| DOI: | 10.1021/acs.accounts.6b00475 |