Preliminary study of the effects of age and Type-2 diabetes on the release of interleukin (lL)-6, IL-10, TNF-ALPHA, and cortisol in respose to acute exercise

The immune response to exercise results in the release of inflammatory markers. This study examined the effects of age and type-2 diabetes on cytokine response following an acute bout of exercise. Five older type-2 diabetics (OD) (mean age 82 plus or minus 3 years), 5 non-diabetic (79 plus or minus 6 years) older adults (OND), and 5 young healthy (YH) (26 plus or minus 3years) control subjects were studied before and following a sub-maximal incremental treadmill test. Venous blood samples were collected immediately pre-and 5 minutes post-exercise, and plasma was analyzed for interleukin (IL)-6, IL-10, tumor necrosis factor-a (TNF-a), C-reactive protein (CRP), and cortisol levels. Cortisol levels were significantly elevated post-exercise (p60%HRR). A significant main effect for group was found for IL-6 (p