PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer

Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PD...

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Veröffentlicht in:	Biochemistry (Moscow) 2017-08, Vol.82 (8), p.887-893
Hauptverfasser:	Vinogradova, T. V., Sverdlov, E. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Cancer metastasis Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Development and progression Developmental biology Disease Progression Embryogenesis Embryonic Development Embryonic growth stage Gene expression Genetic aspects Health aspects Homeobox genes Homeodomain Proteins - metabolism Humans Life Sciences Microbiology Mini-Review Pancreas Pancreas - growth & development Pancreas - metabolism Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein expression ras Proteins - genetics ras Proteins - metabolism Regulators Reviews Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tumorigenesis
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