PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer

PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer

Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PD...

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Veröffentlicht in:Biochemistry (Moscow) 2017-08, Vol.82 (8), p.887-893
Hauptverfasser: Vinogradova, T. V., Sverdlov, E. D.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Cancer metastasis
Carcinoma, Pancreatic Ductal - metabolism
Carcinoma, Pancreatic Ductal - pathology
Development and progression
Developmental biology
Disease Progression
Embryogenesis
Embryonic Development
Embryonic growth stage
Gene expression
Genetic aspects
Health aspects
Homeobox genes
Homeodomain Proteins - metabolism
Humans
Life Sciences
Microbiology
Mini-Review
Pancreas
Pancreas - growth & development
Pancreas - metabolism
Pancreatic cancer
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Protein expression
ras Proteins - genetics
ras Proteins - metabolism
Regulators
Reviews
Trans-Activators - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Tumorigenesis
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Zusammenfassung:Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.
ISSN:0006-2979
1608-3040
DOI:10.1134/S000629791708003X