Predictors of survival in head and neck mucosal melanoma
•This is the largest study of head and neck mucosal melanomas to date.•Prognosis remains poor with a 27.9% 5-year overall survival.•Paranasal sinus tumors have worse prognosis than other head and neck sites.•Surgery with or without radiation has better survival than non-surgical approaches.•There ha...
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Veröffentlicht in: | Oral oncology 2017-10, Vol.73, p.36-42 |
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Sprache: | eng |
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Zusammenfassung: | •This is the largest study of head and neck mucosal melanomas to date.•Prognosis remains poor with a 27.9% 5-year overall survival.•Paranasal sinus tumors have worse prognosis than other head and neck sites.•Surgery with or without radiation has better survival than non-surgical approaches.•There has been increased use of multi-modality treatment over the last decade.
To evaluate hospital-based data of head and neck mucosal melanoma patients in order to identify predictors of survival.
The National Cancer Data Base was used to identify 1368 patients with head and neck mucosal melanoma diagnosed between the years of 2004 and 2012. The Kaplan-Meier method was utilized to estimate overall survival, and multivariate Cox regression analyses were performed to assess the impact of covariates on survival after adjusting for confounding variables.
Median follow-up was 55.2months. Median survival of all patients was 29.3months, and the 5-year survival was 27.4%. After adjusting for other prognostic factors in multivariate analysis, paranasal sinus location [hazard ratio (HR)=1.54, 95% Confidence Interval (CI)=1.30–1.82, P |
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ISSN: | 1368-8375 1879-0593 |
DOI: | 10.1016/j.oraloncology.2017.08.002 |