Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block

Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block

Org 25969 is a cyclodextrin compound designed to reverse a rocuronium-induced neuromuscular block. The aim of this study was to explore the efficacy, dose–response relation and safety of Org 25969 for reversal of a prolonged rocuronium-induced neuromuscular block. Thirty anaesthetized adult patients...

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Veröffentlicht in:British journal of anaesthesia : BJA 2006-01, Vol.96 (1), p.36-43
Hauptverfasser: Shields, M, Giovannelli, M, Mirakhur, R.K., Moppett, I, Adams, J, Hermens, Y
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Androstanols - antagonists & inhibitors
Androstanols - pharmacology
Anesthesia
Anesthesia Recovery Period
Anesthesia, General
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
antagonists
antagonists, Org 25969 (sugammadex)
Biological and medical sciences
cyclodextrins
Dose-Response Relationship, Drug
Double-Blind Method
Electric Stimulation
Female
gamma-Cyclodextrins - adverse effects
gamma-Cyclodextrins - pharmacology
Humans
Male
Medical sciences
Middle Aged
Monitoring, Intraoperative - methods
Myography
Neuromuscular Blockade
neuromuscular blocking agents
neuromuscular blocking agents, rocuronium
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiology
Neuromuscular Nondepolarizing Agents - antagonists & inhibitors
Neuromuscular Nondepolarizing Agents - pharmacology
Org 25969 (sugammadex)
rocuronium
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Beschreibung
Zusammenfassung:Org 25969 is a cyclodextrin compound designed to reverse a rocuronium-induced neuromuscular block. The aim of this study was to explore the efficacy, dose–response relation and safety of Org 25969 for reversal of a prolonged rocuronium-induced neuromuscular block. Thirty anaesthetized adult patients received rocuronium 0.6 mg kg−1 as an initial dose followed by increments to maintain a deep block at a level of
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/aei314