Harnessing multimodality to enhance quantification and reproducibility of in vivo molecular imaging data

We have combined the K ODAK In-Vivo Multispectral Imaging System FX with a new animal rotation module. This module enables the precise co-registration of X-ray images with spectrally unmixed fluorescence images of mice rotated through various craniocaudal angles. The X-ray images were critical for reproducing and optimizing the spatial orientation of animals at angles that maximized the luminescence intensity of the optical signal.