A versatile platform for adding functional properties to amyloid fibrils

A versatile platform for adding functional properties to amyloid fibrils

Herein we report the design, synthesis, and testing of prototype members of a family of amyloid-binding molecular tools that can manipulate the fibrils by giving them various new functional properties. Potential applications include manipulating disease-relevant fibrils, developing novel functional...

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Veröffentlicht in:Organic & biomolecular chemistry 2017-10, Vol.15 (38), p.8023-8027
Hauptverfasser: Fontaine, Devon F A, Ivancic, Valerie A, Reardon, Michael B, Lazo, Noel D, Jakobsche, Charles E
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein we report the design, synthesis, and testing of prototype members of a family of amyloid-binding molecular tools that can manipulate the fibrils by giving them various new functional properties. Potential applications include manipulating disease-relevant fibrils, developing novel functional nanomaterials, and studying the molecular details of fibril structures.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob02042b