Synthesis and antitumor activity of amine analogs of irofulven
Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-12, Vol.17 (24), p.6770-6772 |
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| container_end_page | 6772 |
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| container_issue | 24 |
| container_start_page | 6770 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 17 |
| creator | McMorris, Trevor C. Chimmani, Ramesh Gurram, Mahender Staake, Michael D. Kelner, Michael J. |
| description | Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs. |
| doi_str_mv | 10.1016/j.bmcl.2007.10.040 |
| format | Article |
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Drug treatments</subject><subject>Reductive amination</subject><subject>Sesquiterpenes - chemical synthesis</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - toxicity</subject><subject>Staudinger ligation</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIL3prnbRp04IIsvgFCx7cg7eQJhPN0o81aRf239uyhb15GAbeeWYYHkKuKUQUaHa_icpaVVEMwIcgAgYnZE5ZxsKEQXpK5lBkEOYF-5qRC-83AJQBY-dkRnnBOY_jOXn83DfdD3rrA9nooTrb9XXrAqk6u7PdPmhNIGvb4DCTVfvtx8C61vTVDptLcmZk5fFq6guyfnleL9_C1cfr-_JpFSpG0y40pcrSRGmMIUlKGWvDQRuZaZrrBBRCSlWuIc0zwxhqTFkpk4JpJSkmMk8W5O5wduva3x59J2rrFVaVbLDtvaAFA86BD2B8AJVrvXdoxNbZWrq9oCBGaWIjRmlilDZmg7Rh6Wa63pc16uPKZGkAbidAeiUr42SjrD9yRVZAxkfu4cDhoGJn0QmvLDYKtXWoOqFb-98ff-4Mi4Y</recordid><startdate>20071215</startdate><enddate>20071215</enddate><creator>McMorris, Trevor C.</creator><creator>Chimmani, Ramesh</creator><creator>Gurram, Mahender</creator><creator>Staake, Michael D.</creator><creator>Kelner, Michael J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20071215</creationdate><title>Synthesis and antitumor activity of amine analogs of irofulven</title><author>McMorris, Trevor C. ; Chimmani, Ramesh ; Gurram, Mahender ; Staake, Michael D. ; Kelner, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-fbc653cde2033ba2df70dfa6d18d30ce051c8d0586f44ede54ba394dca1e3a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Amines - chemistry</topic><topic>Analogs synthesis</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Alkylating - chemical synthesis</topic><topic>Antineoplastic Agents, Alkylating - chemistry</topic><topic>Antineoplastic Agents, Alkylating - toxicity</topic><topic>Antitumor activity</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>General aspects</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Irofulven</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. 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| ispartof | Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6770-6772 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenocarcinoma - pathology Amines - chemistry Analogs synthesis Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - toxicity Antitumor activity Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects General aspects Humans Inhibitory Concentration 50 Irofulven Medical sciences Molecular Structure Pharmacology. Drug treatments Reductive amination Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sesquiterpenes - toxicity Staudinger ligation Structure-Activity Relationship |
| title | Synthesis and antitumor activity of amine analogs of irofulven |
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