Synthesis and antitumor activity of amine analogs of irofulven

Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-12, Vol.17 (24), p.6770-6772
Hauptverfasser:	McMorris, Trevor C., Chimmani, Ramesh, Gurram, Mahender, Staake, Michael D., Kelner, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Amines - chemistry Analogs synthesis Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - toxicity Antitumor activity Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects General aspects Humans Inhibitory Concentration 50 Irofulven Medical sciences Molecular Structure Pharmacology. Drug treatments Reductive amination Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sesquiterpenes - toxicity Staudinger ligation Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.10.040