Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates

Antibody–drug conjugates (ADCs) developed using the valine-citrulline-MMAE (vc-MMAE) platform, consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile vc linker. Recently, clinical data for a variety of vc-MMAE ADCs has become availab...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2017-12, Vol.44 (6), p.537-548
Hauptverfasser:	Kågedal, Matts, Gibiansky, Leonid, Xu, Jian, Wang, Xin, Samineni, Divya, Chen, Shang-Chiung, Lu, Dan, Agarwal, Priya, Wang, Bei, Saad, Ola, Koppada, Neelima, Fine, Bernard M., Jin, Jin Y., Girish, Sandhya, Li, Chunze
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Body weight Citrulline Citrulline - chemistry Citrulline - pharmacokinetics Citrulline - therapeutic use Cohort Studies Conjugates Drug dosages Female Humans Immunoconjugates - chemistry Immunoconjugates - pharmacokinetics Immunoconjugates - therapeutic use Male Males Middle Aged Models, Biological Monoclonal antibodies Neoplasms - drug therapy Neoplasms - metabolism Oligopeptides - chemistry Oligopeptides - pharmacokinetics Oligopeptides - therapeutic use Original Paper Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacy Valine Valine - chemistry Valine - pharmacokinetics Valine - therapeutic use Veterinary Medicine/Veterinary Science Young Adult
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