Regioselective Intermolecular Allylic C−H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates

A method for catalytic intermolecular allylic C−H amination of trans‐disubstituted olefins is reported. The reaction is efficient for a range of common nitrogen nucleophiles bearing one electron‐withdrawing group, and proceeds under mild reaction conditions. Good levels of regioselectivity are observed for a wide range of electronically diverse trans‐β‐alkyl styrene substrates. A method for catalytic intermolecular allylic C−H amination of trans‐disubstituted olefins has been developed that is efficient for a range of common nitrogen nucleophiles bearing one electron‐withdrawing group (EWG), and proceeds under mild reaction conditions. Good levels of regioselectivity are observed for a wide range of electronically diverse trans‐β‐alkyl styrene substrates.