N‐Acetylcysteine Improves the Clinical Conditions of Mustard Gas‐Exposed Patients with Normal Pulmonary Function Test

: Administration of N‐acetylcysteine may be effective in diseases caused by oxidative–antioxidative imbalance. We aimed to determine the effect administration for 4 months of N‐acetylcysteine (1200 mg daily) on sulfur mustard‐induced bronchiolitis obliterans in patients with normal pulmonary function test. In a double‐blind clinical trial, 144 patients with bronchiolitis obliterans due to sulfur mustard and bronchiolitis obliterans syndrome class 0, randomly entered to group 1 (n = 72, N‐acetylcysteine) and group 2 (n = 72, placebo). The changes in dyspnoea, wake‐up dyspnoea, cough and sputum were measured after 4 months using a ‘delta value’ (i.e. symptom score after 4 months – symptom score before the trial). Spirometric findings were measured at the beginning of the trial, 2 months later and 4 months later. Dyspnoea (delta value: –0.78 (0.61), P