Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics

The neurotoxicity of manganese [Mn] is due in part to glutamate excitotoxicity. Release of ATP by astrocytes is a critical modulator of glutamatergic neurotransmission, which is regulated by calcium (Ca 2+) waves that propagate through astrocytic networks in response to synaptic activity. It was pos...

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Veröffentlicht in:	Brain research 2006-10, Vol.1113 (1), p.210-219
Hauptverfasser:	Tjalkens, Ronald B., Zoran, Mark J., Mohl, Brianne, Barhoumi, Roula
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - pharmacology Analysis of Variance Animals Animals, Newborn Astrocyte Astrocytes - drug effects Astrocytes - ultrastructure Biological and medical sciences Calcium - metabolism Calcium signaling Calcium Signaling - drug effects Cells, Cultured Cerebral Cortex - cytology Dose-Response Relationship, Drug Endoplasmic Reticulum - drug effects Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry - methods Indoles Intracellular Fluid - drug effects Intracellular Fluid - metabolism Isolated neuron and nerve. Neuroglia Manganese Manganese - pharmacology Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Purinergic receptor Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Ruthenium Compounds - pharmacology Time Factors Vertebrates: nervous system and sense organs
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