A Mild Rhodium Catalyzed Direct Synthesis of Quinolones from Pyridones: Application in the Detection of Nitroaromatics

A rhodium catalyzed direct regioselective oxidative annulation by double C–H activation is described to synthesize highly substituted quinolones from pyridones. The reaction proceeds at mild conditions with broad scope and wide functional group tolerance. These novel quinolones were explored to reco...

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Veröffentlicht in:Journal of organic chemistry 2017-10, Vol.82 (20), p.10989-10996
Hauptverfasser: Biswas, Aniruddha, Giri, Dipanjan, Das, Debapratim, De, Anurima, Patra, Sanjib K, Samanta, Rajarshi
Format: Artikel
Sprache:eng
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Zusammenfassung:A rhodium catalyzed direct regioselective oxidative annulation by double C–H activation is described to synthesize highly substituted quinolones from pyridones. The reaction proceeds at mild conditions with broad scope and wide functional group tolerance. These novel quinolones were explored to recognize nitroaromatic compounds.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b01932