Mechanical particle coating using polymethacrylate nanoparticle agglomerates for the preparation of controlled release fine particles: The relationship between coating performance and the characteristics of various polymethacrylates

[Display omitted] We aimed to understand the factors controlling mechanical particle coating using polymethacrylate. The relationship between coating performance and the characteristics of polymethacrylate powders was investigated. First, theophylline crystals were treated using a mechanical powder...

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Veröffentlicht in:	International journal of pharmaceutics 2017-10, Vol.532 (1), p.318-327
Hauptverfasser:	Kondo, Keita, Kato, Shinsuke, Niwa, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Delayed-Action Preparations - chemistry Desiccation Drug Compounding - methods Drug Liberation Dry fine particle coating Glass transition temperature Grindability Mechanical powder processing Nanoparticles - chemistry Polymethacrylate Polymethacrylic Acids - chemistry Powders Spray freeze drying Surface Properties Theophylline - chemistry Transition Temperature
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Zusammenfassung:	[Display omitted] We aimed to understand the factors controlling mechanical particle coating using polymethacrylate. The relationship between coating performance and the characteristics of polymethacrylate powders was investigated. First, theophylline crystals were treated using a mechanical powder processor to obtain theophylline spheres (
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2017.09.021