Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis

Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis

Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls...

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Veröffentlicht in:Schizophrenia research 2018-05, Vol.195, p.402-405
Hauptverfasser: Joaquim, Helena P.G., Zanetti, Marcus V., Serpa, Mauricio H., Van de Bilt, Martinus T., Sallet, Paulo C., Chaim, Tiffany M., Busatto, Geraldo F., Gattaz, Wagner F., Talib, Leda L.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antipsychotic treatment
Female
First-episode psychosis
Glycogen Synthase Kinase 3 beta - blood
GSK3B
Humans
Male
Non-affective psychosis
Phosphorylation
Psychotic Disorders - blood
Schizophrenia
Schizophrenia - blood
Statistics, Nonparametric
Young Adult
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Beschreibung
Zusammenfassung:Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls (n=77). At baseline GSK3B total level was higher in patients (p
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2017.08.062