MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG‐I expression in lung epithelial cells

The pattern recognition receptor retinoic acid‐inducible gene I (RIG‐I) reportedly plays a key role in sensing influenza A virus (IAV) infection and activating type I interferon (IFN) response. MCP‐1‐induced protein 1 (MCPIP1) can directly degrade cytokine mRNAs, such as IL‐6, IL‐12, IL‐1β, and IL‐2...

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Veröffentlicht in:	Journal of medical virology 2018-02, Vol.90 (2), p.204-211
Hauptverfasser:	Sun, Xiaoning, Feng, Wenjing, Guo, Yidi, Wang, Qi, Dong, Chunyan, Zhang, Maolin, Guan, Zhenhong, Duan, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Actinomycin Epithelial cells Epithelial Cells - immunology Epithelial Cells - virology Gene expression Humans Immune response Immune system Immunity, Innate Infections Influenza Influenza A Influenza A virus - immunology influenza virus Innate immunity Interferon Interleukin 1 Interleukin 12 Interleukin 2 Interleukin 6 Lung - immunology Lung - virology Lungs MCPIP1 Monocyte chemoattractant protein 1 mRNA Mutants NS1 Pattern recognition Pattern recognition receptors Proteins Receptors, Retinoic Acid - metabolism Retinoic acid Ribonuclease Ribonucleases - metabolism RIG‐I Transcription Factors - metabolism Virology Viruses
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