Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants

Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants

To determine whether a variant of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1*6) is a risk factor for prolonged hyperbilirubinemia in preterm infants. UGT1A1 genotypes in 46 Japanese preterm infants (150 µmol/L (8.77 mg/dL) beyond 14 days of life. In the case group, 41 of...

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Veröffentlicht in:The Journal of pediatrics 2017-11, Vol.190, p.159-162.e1
Hauptverfasser: Yanagi, Takahide, Nakahara, Sayuri, Maruo, Yoshihiro
Format: Artikel
Sprache:eng
Schlagworte:
Asian Continental Ancestry Group - genetics
Bilirubin - blood
Case-Control Studies
Female
Genotype
Glucuronosyltransferase - genetics
Humans
Hyperbilirubinemia, Neonatal - genetics
Infant, Newborn
Infant, Premature
Japan
jaundice
Male
neonatal hyperbilirubinemia
p.G71R
Polymerase Chain Reaction
Polymorphism, Genetic
premature baby
Retrospective Studies
Risk Factors
UGT1A1
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Zusammenfassung:To determine whether a variant of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1*6) is a risk factor for prolonged hyperbilirubinemia in preterm infants. UGT1A1 genotypes in 46 Japanese preterm infants (150 µmol/L (8.77 mg/dL) beyond 14 days of life. In the case group, 41 of 46 infants (89.1%) had a polymorphic variant, c.211G>A, p.G71R (UGT1A1*6). In the control group, 7 of 38 (18.4%) had UGT1A1*6. The allele frequency of UGT1A1*6 was 0.641 in the prolonged hyperbilirubinemia group, which was significantly higher than in the control group (0.092; P 
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2017.07.014