Synthesis of Functionalized Quinolines through a Reaction of Amides and Alkynes Promoted by Triflic Anhydride/Pyridine

A concise, novel and flexible metal‐free single step to synthesize functionalized quinolines is reported. Triflic anhydride‐mediated (Tf2O) activation of amides is discussed in the presence of pyridine to offer strong electrophiles, thereby showcasing excellent productivity, high regio‐ and chemoselectivity, and widely tolerable substrates. This approach provides a straightforward and efficient way to construct azaheterocycle structures. Various functionalized quinolines are readily obtained through a metal‐free novel process. The method offers a straightforward and efficient way to construct azaheterocycle structures with excellent productivity, high regio‐ and chemoselectivity.