Synthesis and neuroprotective effects of serofendic acid analogues

Analogues of serofendic acid were prepared and their protective effects against l-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Analogues of serofendic acid were prepared and their protective effects against l-glutamate (Glu)-induced neurotoxicit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-10, Vol.16 (19), p.5080-5083
Hauptverfasser:	Terauchi, Taro, Doko, Takashi, Yonaga, Masahiro, Kajiwara, Akiharu, Niidome, Tetsuhiro, Taguchi, Ryota, Kume, Toshiaki, Akaike, Akinori, Sugimoto, Hachiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atisane Biological and medical sciences Cells, Cultured Diterpenes - chemical synthesis Diterpenes - pharmacology Glutamate Glutamic Acid - adverse effects Medical sciences Neurons - drug effects Neuropharmacology Neuroprotective Neuroprotective agent Neuroprotective Agents - chemical synthesis Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - prevention & control Pharmacology. Drug treatments Rats Serofendic acid Structure-Activity Relationship
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Zusammenfassung:	Analogues of serofendic acid were prepared and their protective effects against l-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Analogues of serofendic acid were prepared and their protective effects against l-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Some analogues exhibited similar neuroprotective activity to that of serofendic acid.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.07.038