Exploiting Overlapping Advantages of In Vitro and In Cellulo Selection Systems to Isolate a Novel High-Affinity cJun Antagonist

We have combined two peptide library-screening systems, exploiting the benefits offered by both to select novel antagonistic agents of cJun. CIS display is an in vitro cell-free system that allows very large libraries (≤1014) to be interrogated. However, affinity-based screening conditions can poorl...

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Veröffentlicht in:	ACS chemical biology 2017-10, Vol.12 (10), p.2579-2588
Hauptverfasser:	Baxter, Daniel, Ullman, Christopher G, Frigotto, Laura, Mason, Jody M
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Complementation Test JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors Peptide Library Peptides - chemistry Peptides - pharmacology Protein Binding Protein Conformation
Online-Zugang:	Volltext
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