Impact of Laboratory Cross-Contamination on Molecular Epidemiology Studies of Tuberculosis

Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a g...

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Veröffentlicht in:	Journal of Clinical Microbiology 2006-08, Vol.44 (8), p.2967-2969
Hauptverfasser:	Martínez, Miguel, García de Viedma, Darío, Alonso, María, Andrés, Sandra, Bouza, Emilio, Cabezas, Teresa, Cabeza, Isabel, Reyes, Armando, Sánchez-Yebra, Waldo, Rodríguez, Manuel, Sánchez, M. Isabel, Rogado, M. Cruz, Fernández, Rosa, Peñafiel, Teresa, Martínez, Juan, Barroso, Pilar, Lucerna, M. Ángeles, Diez, L. Felipe, Gutiérrez, Carmelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial Typing Techniques Biological and medical sciences Diagnostic Errors Equipment Contamination Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious diseases Medical sciences Microbiology Molecular Epidemiology Mycobacteriology and Aerobic Actinomycetes Mycobacterium tuberculosis Mycobacterium tuberculosis - classification Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis and atypical mycobacterial infections
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Zusammenfassung:	Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.00754-06