Treatment outcomes after reduction of the target volume of intensity-modulated radiotherapy following induction chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: A prospective, multi-center, randomized clinical trial

To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. A total number of 212 NP...

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Veröffentlicht in:	Radiotherapy and oncology 2018-01, Vol.126 (1), p.37-42
Hauptverfasser:	Yang, Hongru, Chen, Xin, Lin, Sheng, Rong, Jinfeng, Yang, Mi, Wen, Qinglian, Shang, Changling, He, Lijia, Ren, Peirong, Xu, Shan, Zhang, Jianwen, Liu, Qiaoli, Pang, Haowen, Shi, Xiangxiang, Fan, Juan, Sun, Xiaoyang, Ma, Daiyuan, Tan, Bangxian, Zhang, Tao, Zhang, Ling, Hu, Defeng, Du, Xiaobo, Zhang, Yu, Wen, Shiming, Zhang, Xinping, Wu, Jingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - administration & dosage Carcinoma - drug therapy Carcinoma - pathology Carcinoma - radiotherapy Chemoradiotherapy Cisplatin - administration & dosage Concurrent chemoradiotherapy (CRT) Disease-Free Survival Dose-Response Relationship, Radiation Female Humans Induction Chemotherapy Induction chemotherapy (IC) Intensity-modulated radiation therapy (IMRT) Male Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal carcinoma (NPC) Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoplasm Staging Prospective Studies Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Survival Rate Target delineation Treatment Outcome
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Zusammenfassung:	To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. A total number of 212 NPC patients staged as III–IVb were randomly assigned to group A (n=97) or group B (n=115) in this prospective clinical trial. All patients received IC followed by cisplatin concurrent with IMRT. IMRT was planned using the images of pre-IC in group A and post-IC in group B. The dose received by normal tissues in group B was lower than that of group A (P
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2017.07.020