Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impac...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.) Fla.), 2018-02, Vol.187, p.26-32
Hauptverfasser: Kielsen, Katrine, Shamim, Zaiba, Thiant, Stephanie, Faucher, Sylvie, Decker, Wendy, Christensen, Ib Jarle, Ryder, Lars Peter, Yakoub-Agha, Ibrahim, Müller, Klaus
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Acute graft-versus-host disease
Adolescent
Adult
Aged
Allogeneic HSCT
Child
Child, Preschool
Female
Graft vs Host Disease - epidemiology
Graft vs Host Disease - immunology
Hematopoietic Stem Cell Transplantation
Humans
IL-7Rα SNPs
Infant
Interleukin-7 - immunology
Interleukin-7 Receptor alpha Subunit - immunology
Leukemia - therapy
Lymphoma, Non-Hodgkin - therapy
Male
Middle Aged
Mortality
Myelodysplastic-Myeloproliferative Diseases - therapy
Polymorphism, Single Nucleotide
Soluble IL-7R
T-Lymphocytes - immunology
Thrombocythemia, Essential - therapy
Transplantation, Homologous
Young Adult
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Zusammenfassung:Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during HSCT (from 114ng/ml before to 48ng/ml at day +14 (P
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2017.08.015