Effects of an Alkaline Diet on EGFR-TKI Therapy in EGFR Mutation-positive NSCLC

The acidic tumor microenvironment is associated with progression of cancers. The purpose of this study was to investigate the association between an alkaline diet and the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) patients....

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Veröffentlicht in:	Anticancer research 2017-09, Vol.37 (9), p.5141-5145
Hauptverfasser:	Hamaguchi, Reo, Okamoto, Toshihiro, Sato, Masaaki, Hasegawa, Michiko, Wada, Hiromi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnostic imaging Adenocarcinoma - diet therapy Adenocarcinoma - drug therapy Aged Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - diet therapy Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Disease-Free Survival Erlotinib Hydrochloride - therapeutic use Female Humans Hydrogen-Ion Concentration Kaplan-Meier Estimate Lung Neoplasms - diagnostic imaging Lung Neoplasms - diet therapy Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Middle Aged Mutation Positron Emission Tomography Computed Tomography Protein Kinase Inhibitors - therapeutic use Quinazolines - therapeutic use Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Urine - chemistry
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Zusammenfassung:	The acidic tumor microenvironment is associated with progression of cancers. The purpose of this study was to investigate the association between an alkaline diet and the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) patients. Eleven advanced or recurrent NSCLC patients with EGFR mutations treated with EGFR-TKI after being instructed to follow an alkaline diet were retrospectively evaluated. The median progression-free survival (PFS) and overall survival (OS) were 19.5 (range=3.1-33.8) and 28.5 (range=15.4-46.6) months. The average dosage of EGFR-TKI was 56±22% of the standard dosage. Urine pH was significantly increased after the alkaline diet (6.00±0.38 vs. 6.95±0.55; p
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.11934