In the Hunger Games, the Winner Takes Everything

In the Hunger Games, the Winner Takes Everything

Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimin...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2017-10, Vol.42 (10), p.763-764
Hauptverfasser: Püschel, Franziska, Muñoz-Pinedo, Cristina
Format: Artikel
Sprache:eng
Schlagworte:
AMP-Activated Protein Kinases
AMPK
cancer metabolism
Cell Death
entosis
Glucose
Humans
Hunger
starvation
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Beschreibung
Zusammenfassung:Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimination by winner cells, which endure starvation.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2017.08.004