Associations of ERAP1 coding variants and domain specific interaction with HLA-C∗06 in the early onset psoriasis patients of India

Interferon-γ-induced aminopeptidase ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto MHC class I and presented to the CD8+ T-cells. ERAP1 association and its interaction with HLA-C∗06 is controversial across different populations. We have investigated the associa...

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Veröffentlicht in:	Human immunology 2017-11, Vol.78 (11-12), p.724-730
Hauptverfasser:	Das, Anamika, Chandra, Aditi, Chakraborty, Joyeeta, Chattopadhyay, Abhijit, Senapati, Swapan, Chatterjee, Gobinda, Chatterjee, Raghunath
Format:	Artikel
Sprache:	eng
Schlagworte:	Endoplasmic reticulum aminopeptidase 1 Epistasis Generalized plaque type psoriasis Human Leukocyte Antigen (HLA)-C∗06 Single nucleotide polymorphism
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Zusammenfassung:	Interferon-γ-induced aminopeptidase ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto MHC class I and presented to the CD8+ T-cells. ERAP1 association and its interaction with HLA-C∗06 is controversial across different populations. We have investigated the association and possible functional role of non-synonymous SNPs at different exons of ERAP1 (rs26653: Arg127Pro, rs30187: Lys528Arg and rs27044: Gln730Glu) and their interactions with HLA-C∗06 in psoriasis. Significant associations of HLA-C∗06 (OR=5.47, P
ISSN:	0198-8859 1879-1166
DOI:	10.1016/j.humimm.2017.08.006