Small non-coding RNAs and genomic imprinting

Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q11→q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families....

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Veröffentlicht in:	Cytogenetic and Genome Researchearch 2006-03, Vol.113 (1-4), p.99-108
Hauptverfasser:	Royo, H., Bortolin, M.-L., Seitz, H., Cavaillé, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Chromosome Mapping Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 7 Genomic Imprinting Humans Life Sciences Mice MicroRNAs MicroRNAs - genetics Models, Genetic Regulatory Mechanisms RNA, Messenger RNA, Messenger - genetics RNA, Untranslated RNA, Untranslated - genetics Transcription, Genetic
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Beschreibung
Zusammenfassung:	Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q11→q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications and RNA-mediated gene silencing, respectively. Here, we discuss their potential functions and report the identification of novel small RNA genes lying within (or nearby) known imprinted chromosomal domains.
ISSN:	1424-8581 1424-859X
DOI:	10.1159/000090820