Fetal growth and premature delivery in pregnant women on antiepileptic drugs

Fetal growth and premature delivery in pregnant women on antiepileptic drugs

Objective To evaluate the effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on fetal growth and preterm delivery. Methods This study included singleton liveborn infants born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2016. Da...

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Veröffentlicht in:Annals of neurology 2017-09, Vol.82 (3), p.457-465
Hauptverfasser: Hernández‐Díaz, Sonia, McElrath, Thomas F., Pennell, Page B., Hauser, W. Allen, Yerby, Mark, Holmes, Lewis B.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anticonvulsants - adverse effects
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Antiepileptic agents
Birth weight
Childbirth & labor
Confidence intervals
Convulsions & seizures
Drug delivery systems
Drug development
Drugs
Epilepsy
Epilepsy - drug therapy
Female
Fetal Development - drug effects
Fetuses
Gestational age
Health risk assessment
Humans
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Infants
Lamotrigine
Male
Neonates
Obstetric Labor, Premature - chemically induced
Obstetric Labor, Premature - epidemiology
Population studies
Pregnancy
Premature birth
Prenatal experience
Prenatal exposure
Prevalence
Prospective Studies
Registries
Regression analysis
Regression models
Risk
Risk assessment
Small for gestational age
Topiramate
Young Adult
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Beschreibung
Zusammenfassung:Objective To evaluate the effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on fetal growth and preterm delivery. Methods This study included singleton liveborn infants born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2016. Data were collected prospectively through telephone interviews. The prevalence of preterm birth (
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.25031